Targeted data on protein degraders
Get a structure-activity relationship database that is as targeted as the protein degraders you are developing. With GOSTAR™ TPD, you get detailed, standardized, carefully curated information on over 45,000 targeted protein degraders across all TPD modalities.
GOSTAR™ TPD is both the largest TPD database and also the cleanest, with all data manually curated by expert chemists and having undergone a rigorous, three-tiered QC process.
Discover the power of the largest TPD database
The most comprehensive coverage
- 250+ annotated data fields to explore relationships between chemical, biological, and therapeutic properties.
- 45,000+ degraders
- Coverage of 10 protein degrader modalities
- Data from over 10,000 documents
- 120,000+ SAR data points
Data you can rely on
- Fully manually curated by expert chemists.
- No automated data scraping.
- Every data point undergoes a three-tiered quality control process to ensure maximum accuracy and reliability.
- QMS-ISO-9001:2015 certified
- Check our work! Every data point is linked to the original source for traceability and validation.
Curated for informatics
- Clean, structured data requiring minimal processing for seamless integration into computational models.
- Data available in bulk via flat file, API, or exports.
- Standardized vocabulary and standardized units result in minimal post-processing to use in AI/ML models.
- Available in multiple convenient formats including flat files, hierarchical files, semantic format, Oracle databases, MySQL™ databases etc.,
Unbeatable relevance
- GOSTAR™ TPD is a true Structure-Activity Relationship (SAR) database, with data curated specifically for drug discovery workflows.
- Focus on what matters from the start. GOSTAR™ TPD has none of the irrelevant data found in broader chemistry databases.
The most timely updates
- GOSTAR TPD™ is updated every month.
- For critical data and urgent applications, request custom curation of the desired data at the frequency you want, and be updated in as little as 24 hours after publication of the data.
- With over 10K+ patents and publications screened, get data on novel degraders from the earliest stages.
When content is key, you need GOSTAR™ TPD
45
Unique degraders
120
SAR data points
1.5
Biological targets
10
Modalities
100
Companies & institutes
10
Documents screened
45
Unique degraders
1.5
Biological targets
100
Companies & institutes
120
SAR data points
10
Modalities
10
Documents screened
Experience the future of TPD discovery Explore – GOSTAR™ TPD today!
Select your role & see how GOSTAR™ TPD can empower you
- AI, informaticians & data scientists
- Medicinal chemists
- Drug development executives and strategic professionals
- AIl drug development and discovery professionals
AI, informaticians & data scientists
Building AI/ML models can be difficult when the modality is new and the data available is limited. That is a significant part of the reason we built GOSTAR™ TPD in the first place.
The most data available
GOSTAR™ TPD provides you with a huge chunk of the publicly available data on targeted protein degraders: Over 120K data points on 45K degraders across 10 modalities targeting over 1.5K protein targets.
Focus on your models, not cleaning data
We use standardized vocabulary and units to ensure the data is as clean and harmonized as possible. GOSTAR™ TPD’s machine-friendly data and formats help you maintain your focus on building models.
Take comfort in quality
You can only make predictive models from accurate data. Concerned if your data is accurate enough? Rest easy with GOSTAR™ TPD. Our three tiered, QMS-ISO-certified, quality control process provides you with unparalleled data quality.
Medicinal chemists
You’re a medicinal chemist? Cool! We are too, and we built GOSTAR™ TPD to be a database we would want to use ourselves: comprehensive, accurate, and incredibly easy to use.
Zoom right in
With a powerful and user-friendly interface and a database which focuses on SAR data and only includes protein degraders, you can find the data you need in seconds. From there, you can deep dive, explore adjacent spaces, and export your data set of interest.
All signal, no noise
GOSTAR™ is the only SAR database that is designed by medicinal chemists, for medicinal chemists. Our harmonized data sets are curated to contain the most relevant data for pharmaceutical design and discovery.
The most comprehensive data
With coverage of over 45,000 targeted protein degraders and growing every week, GOSTAR™ TPD is the most comprehensive TPD data set available by far.
Drug development executives and strategic professionals
The TPD landscape is rapidly evolving and growing, with more degraders and more competitors entering the field almost continuously. Understanding how the landscape is changing will empower you to make the optimal decisions for your own pipeline.
More compounds, curated earlier and sooner
Don’t wait for compounds to go into preclinical trials. GOSTAR™ TPD curates degraders from patents, scientific publications, and many other sources the moment they are published. With updates every month and the option to receive targeted updates even faster, you can have the most up-to-date view of the TPD landscape.
Find quickly. Interrogate meaningfully
With powerful, intuitive search, helpful tools, flexible exports, and more, GOSTAR™ TPD makes it easy to find the data you need quickly and thoroughly review modalities and targets of interest.
Make confident pipeline decisions
The more of the chemical space you can see, the better armed you are to make confident pipeline decisions. GOSTAR™ TPD contains the most comprehensive TPD dataset, and our three tiered, QMS-ISO-certified, quality control process means you can be confident in its quality.
AIl drug development and discovery professionals
Targeted protein degraders are a unique class of molecules with similarly unique properties and activities. This distinctiveness from other pharmaceutical modalities merits a unique database.
GOSTAR™ TPD delivers comprehensive data from patents, journals, regulatory submissions and much more. With over 45,000 TPDs in the GOSTAR™ database, it is the most comprehensive and authoritative source on this rapidly evolving therapeutic modality. The flexible delivery of this rich dataset enables you to empower your TPD development efforts however you see fit.
Quantity and quality
With GOSTAR™ TPD, you aren’t only getting data on over 45k TPDs. You are getting the confidence needed to make decisions with conviction. All of GOSTAR™ TPD’s data is manually curated by medicinal chemistry experts and undergoes a three-tiered, QMS-ISO-certified quality control process. This scale and rigor means GOSTAR™ TPD is the most faithful representation of the known TPD space.
The data you need, how you need it
Need data in bulk to fuel AI/ML drug discovery algorithms? Want to easily explore various degrader modalities or targets and then easily export your findings in editable formats? Want the most up-to-date knowledge of a particular chemical space? GOSTAR™ TPD can deliver the data you need, however and whenever you need it. We offer a range of options for accessing the data from a flat file to rapid-turnaround custom curation.
Fully traceable
Traceability is not something you can compromise on in pharmaceutical research. GOSTAR™ TPD ensures all the data which goes into your research and decision-making can be attributed to the original source. Every data point is referenced and linked.
AI, informaticians & data scientists
Building AI/ML models can be difficult when the modality is new and the data available is limited. That is a significant part of the reason we built GOSTAR™ TPD in the first place.
The most data available
GOSTAR™ TPD provides you with a huge chunk of the publicly available data on targeted protein degraders: Over 120K data points on 45K degraders across 10 modalities targeting over 1.5K protein targets.
Focus on your models, not cleaning data
We use standardized vocabulary and units to ensure the data is as clean and harmonized as possible. GOSTAR™ TPD’s machine-friendly data and formats help you maintain your focus on building models.
Take comfort in quality
You can only make predictive models from accurate data. Concerned if your data is accurate enough? Rest easy with GOSTAR™ TPD. Our three tiered, QMS-ISO-certified, quality control process provides you with unparalleled data quality.
Medicinal chemists
You’re a medicinal chemist? Cool! We are too, and we built GOSTAR™ TPD to be a database we would want to use ourselves: comprehensive, accurate, and incredibly easy to use.
Zoom right in
With a powerful and user-friendly interface and a database which focuses on SAR data and only includes protein degraders, you can find the data you need in seconds. From there, you can deep dive, explore adjacent spaces, and export your data set of interest.
All signal, no noise
GOSTAR™ is the only SAR database that is designed by medicinal chemists, for medicinal chemists. Our harmonized data sets are curated to contain the most relevant data for pharmaceutical design and discovery.
The most comprehensive data
With coverage of over 45,000 targeted protein degraders and growing every week, GOSTAR™ TPD is the most comprehensive TPD data set available by far.
Drug development executives and strategic professionals
The TPD landscape is rapidly evolving and growing, with more degraders and more competitors entering the field almost continuously. Understanding how the landscape is changing will empower you to make the optimal decisions for your own pipeline.
More compounds, curated earlier and sooner
Don’t wait for compounds to go into preclinical trials. GOSTAR™ TPD curates degraders from patents, scientific publications, and many other sources the moment they are published. With updates every month and the option to receive targeted updates even faster, you can have the most up-to-date view of the TPD landscape.
Find quickly. Interrogate meaningfully
With powerful, intuitive search, helpful tools, flexible exports, and more, GOSTAR™ TPD makes it easy to find the data you need quickly and thoroughly review modalities and targets of interest.
Make confident pipeline decisions
The more of the chemical space you can see, the better armed you are to make confident pipeline decisions. GOSTAR™ TPD contains the most comprehensive TPD dataset, and our three tiered, QMS-ISO-certified, quality control process means you can be confident in its quality.
AIl drug development and discovery professionals
Targeted protein degraders are a unique class of molecules with similarly unique properties and activities. This distinctiveness from other pharmaceutical modalities merits a unique database.
GOSTAR™ TPD delivers comprehensive data from patents, journals, regulatory submissions and much more. With over 45,000 TPDs in the GOSTAR™ database, it is the most comprehensive and authoritative source on this rapidly evolving therapeutic modality. The flexible delivery of this rich dataset enables you to empower your TPD development efforts however you see fit.
Quantity and quality
With GOSTAR™ TPD, you aren’t only getting data on over 45k TPDs. You are getting the confidence needed to make decisions with conviction. All of GOSTAR™ TPD’s data is manually curated by medicinal chemistry experts and undergoes a three-tiered, QMS-ISO-certified quality control process. This scale and rigor means GOSTAR™ TPD is the most faithful representation of the known TPD space.
The data you need, how you need it
Need data in bulk to fuel AI/ML drug discovery algorithms? Want to easily explore various degrader modalities or targets and then easily export your findings in editable formats? Want the most up-to-date knowledge of a particular chemical space? GOSTAR™ TPD can deliver the data you need, however and whenever you need it. We offer a range of options for accessing the data from a flat file to rapid-turnaround custom curation.
Fully traceable
Traceability is not something you can compromise on in pharmaceutical research. GOSTAR™ TPD ensures all the data which goes into your research and decision-making can be attributed to the original source. Every data point is referenced and linked.
Rich TPD data on your terms
Powerful, intuitive search | Segmented data analysis | User-friendly SAR tool | Report generation | Flexible export options
Get a flat file or use our simple web APIs | Get the entire TPD database or any subset | Receive regular or on-demand updates
Obtain data on any known TPDs | Leverages our proven data model | Three-tiered QC for even greater accuracy | Stay up-to-date: < 48 hour turnaround time on new data | Optional custom reports formatted according to your needs
Fuel your TPD research. See GOSTAR™ TPD today!
Blog
Step-by-step walkthrough of targeted protein degradation: Understanding the science and impact
Protein degradation is an important process in the cell. It helps keep the cell healthy and functioning properly. Targeted protein degradation (TPD) is a new treatment that uses this process to eliminate harmful proteins related to diseases. Instead of only stopping a protein’s function, TPD focuses on completely removing it from the cell. This gives a powerful new approach to finding and developing drugs.
Knowledge hub
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Frequently asked questions
I am working on a specific degrader modality. Is it included in GOSTAR™ TPD?
GOSTAR TPD includes data on compounds in the following degrader modalities:
- Monovalent degraders
- Bivalent degraders
- Other UPS-targeting modalities
How frequently is GOSTAR™ TPD updated?
On average, GOSTAR TPD is updated every month. If you need more frequent updates, you can request updates on your specific area of interest as frequently as you need.
What types of drug properties are curated?
We curate a nearly comprehensive range of activity, affinity, ADME, toxicology, physiochemical, and other data relevant to pharmaceutical design and discovery. These include, but are not limited to:
- Biochemical assay endpoints
- Bioactivity
- Binding affinity
- Cell-based assay endpoints
- Chemical structure
- Molecular descriptors
- Permeability
- Physicochemical properties
- Solubility
- Toxicity
Do you allow exports of the data from the user interface? What formats are available?
Yes, graphical interface users can export data. Available formats are SDF, CSV, and TSV.
Find your next breakthrough with GOSTAR™ TPD
Get access to the richest, most relevant data for targeted protein degrader research with GOSTAR™ TPD – your key to novel designs, optimized SAR, and predictive insights. Request a free demo today!
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